Global optimization approaches in protein folding and peptide docking
نویسندگان
چکیده
The recent advances in genetic engineering, high powered computing and global optimization continue to stimulate interest in the area of molecular modeling and protein structure prediction. The goal of these eeorts is the ability to correctly predict native protein conformations and the binding interactions of macromolecules. These two problems currently dominate the eld of computational chemistry and, through the use of detailed molecular models, they have also greatly innuenced research in the area of global optimization. This article examines some aspects related to conformational energy modeling and reviews a variety of global optimization approaches developed for the protein folding and peptide docking problems.
منابع مشابه
Protein Folding and Peptide Docking :
{Global optimization approaches are proposed for addressing both the protein folding and peptide docking problems. In the protein folding problem, the ultimate goal involves predicting the native protein conformation. A common approach, based on the thermodynamic hypothesis, assumes that this conformation corresponds to the structure exhibiting the global minimum free energy. However, molecular...
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